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Cosmetic Dermatology


Perlane® for Deep Wrinkles

California Skin Institute offers Perlane® filler injections as a way to add volume to the treatment site and reduce the appearance of deep wrinkles and creases, such as nasolabial folds. This dermal filler is part of the Restylane® family of fillers, which are based on the moisture-attracting qualities of hyaluronic acid. However, unlike Restylane® or Restylane Silk®, Perlane® is specifically designed to address deeper wrinkles and has been effectively used by our practitioners to treat problems like nasolabial folds and laugh lines throughout California.

What is Perlane®?

Perlane® is an injectable gel that creates volume under the skin to smooth out deep wrinkles and facial lines. This filler is designed specifically to target deeper wrinkles that may be more difficult to treat with other hyaluronic acid fillers.

As such, Perlane® injections are often delivered at deeper skin levels and contain larger hyaluronic acid molecules, to create greater volume increase more efficiently.

How Perlane® Works

The mechanism by which Perlane® filler treats wrinkles relies on the hydrophilic (water-loving) properties of hyaluronic acid. This chemical occurs naturally in our bodies and can hold many times its weight in moisture.

In Perlane®, this acid is delivered in concentrated form, quickly drawing moisture to the target area and providing nearly instantaneous increases in volume under the skin.

Further, Perlane® filler is formulated in a way that slows down the natural breakdown of hyaluronic acid to provide longer-lasting improvements and is prepared in a way that makes it non-immunogenic (your immune system is highly unlikely to respond to the gel with inflammation).

What Perlane® Treats

Perlane® is formulated specifically for deep lines and wrinkles that are not easily treated with other hyaluronic acid fillers. California Skin Institute providers most commonly use Perlane® injections to treat nasolabial folds and laugh lines.

Perlane® typically isn’t injected into the lips, as the size of the hyaluronic acid molecules and unique chemical dynamics of this filler may create a bumpy, misshapen appearance under the thin skin of the lips (something that is not a concern with the thicker skin around the mouth). For lip enhancement injections, Restylane Silk® is typically a much better option.

How Long does Perlane® Last?

Improvements will appear shortly after the Perlane® injections are performed, and typically continue to improve over several days, as the hyaluronic acid draws more moisture to the treatment site.

Upkeep treatments may prolong the effects of this dermal filler.

What to Expect During Perlane® Treatment

During your visit to California Skin Institute, your provider will examine your skin to determine how much Perlane® will be needed for optimal outcomes. Typically, more of this filler is needed for wrinkles that are very deep.

However, it’s also important to retain a natural appearance, as too much of this filler can create an unnatural appearance when you smile.

To create improvements that look natural, your California Skin Institute provider will administer the Perlane® filler at several injection sites, using a very thin needle. Using several injection sites allows the wrinkles to be filled in a balanced way, and a small needle prevents significant bruising or discomfort.

Does Perlane® Hurt?

California Skin Institute providers go to great lengths to ensure the comfort of each patient. As such, we will use either a local anesthetic or a numbing cream to ensure that the Perlane® injections are as painless as possible. The vast majority of patients tolerate this procedure very easily.

To learn more about Perlane®, call a California Skin Institute practice near you or find a location near you and request a consultation!


Treatment results will vary, talk to a practitioner to see if this treatment or procedure is right for you.

Conditions treated by Perlane®

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