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Cosmetic Dermatology

Restylane® Defyne

When visiting California Skin Institute to treat nasolabial folds, patients now have the option to undergo a new procedure called Restylane Defyne. Minimally invasive and virtually painless, Restylane Defyne is a dermal filler that can be administered in just a few minutes, even during your lunch break. This treatment can be a great option for individuals struggling with nasolabial folds; providing outcomes that look and feel natural.

What is Restylane Defyne?

Restylane Defyne is a dermal filler formulated with hyaluronic acid. It was developed by Galderma, the company that brought us other great fillers, like Restylane LyftRestylane Silk, and Restylane Refyne.

However, though Restylane Defyne may be new to the United States, it has already been extensively used in Europe under the Emervel name.

How Restylane Defyne Works

The core idea behind Restylane Defyne is to reduce the appearance of wrinkles by increasing support under the skin. One of the reasons why nasolabial folds develop is the deterioration in collagen and elastin support network, which causes the skin to become inelastic.

Using a filler like Restylane Defyne, your California Skin Institute provider can create a subtle increase in volume at the treatment site, which helps to smooth out the folds. Further, the hyaluronic acid in this filler will draw moisture to the area, thus increasing support and providing greater hydration to skin cells and fibroblasts.

What Restylane Defyne Treats

Restylane Defyne was primarily developed for the treatment of nasolabial folds (the lines that run from the corners of the nose to the corners of the mouth). It’s typically a good choice for this area because the filler is formulated with XpressHAn technology, which allows for greater support while generally being more flexible than traditional hyaluronic acid fillers.

However, Restylane Defyne is not necessarily limited just for use around nasolabial folds, and may be administered to treat other issues, like marionette lines.

How long does Restylane Defyne Last?

One of the benefits of Restylane Defyne is the longevity of the outcomes Further, touch up treatments can be performed to extend positive improvements.

Additionally, this injectable can be combined with other procedures, like Intense Pulsed Lighttherapy, chemical peels, or retinol creams to help you achieve your aesthetic goals.

What to expect during Restylane Defyne Treatment?

When visiting California Skin Institute for Restylane Defyne treatments, keep in mind that your provider can be a great resource for choosing the best injectable treatment in your situation. There are many dermal fillers currently available, and each produces somewhat different outcomes.

Therefore, we work very hard to create a compassionate and comfortable environment here at California Skin Institute, so that you can feel completely free in sharing your aesthetic goals and concerns. Based on your consultation, your provider will help you select the best treatment plan for your unique situation.

When it comes time to administering Restylane Defyne, many patients are surprised by how comfortable the treatment is. Our providers use very small needles and are experts in performing injections in a way that is quick and virtually painless.

Does Restylane Defyne have Side Effects?

Common side effects from Restylane Defyne are typically associated with the injection process rather than the filler itself. During the injection, a small needle will penetrate the skin, which will elicit the body’s inflammatory response. Therefore, it’s common to experience mild redness and inflammation for a few days after treatment.

However, any such side effects are easily addressed with makeup and typically will not impact your social calendar.

Does Restylane Defyne Hurt?

Restylane Defyne injections are virtually painless. Our providers use tiny needles and can even administer a topical anesthetic if requested by the patient.

Your Restylane Defyne Consultation

The best way to see if Restylane Defyne is the right choice for you is to schedule a consultation with a California Skin Institute provider. Simply call a practice near you or find a location near you and request a consultation!


Treatment results will vary, talk to a practitioner to see if this treatment or procedure is right for you.

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